The innate immune response in ischemic acute kidney injury
نویسندگان
چکیده
منابع مشابه
Reduction of hemorrhagic shock–induced acute kidney injury by lower limb ischemic preconditioning in rats
Introduction: During hemorrhagic shock (HS), the kidneys are one of the primary target organs involved. Oxidative stress is shown to be enhanced in different models of acute kidney injury (AKI). Remote ischemic preconditioning (RPC) by brief limb ischemia is considered to be a safe method to protect different organs from further damage. In this study, we investigated the effects of brief hind l...
متن کاملAdvances in understanding ischemic acute kidney injury
Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusses recent developments in the understanding of ischemic AKI pathophysiology, the emerging relationship between ischemic AKI and develop...
متن کاملCellular pathophysiology of ischemic acute kidney injury.
Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here, we review the major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease. Better understanding of ...
متن کاملInnate Immune Response in Kidney Ischemia/Reperfusion Injury: Potential Target for Therapy
Acute kidney injury caused by ischemia and subsequent reperfusion is associated with a high rate of mortality and morbidity. Ischemia/reperfusion injury in kidney transplantation causes delayed graft function and is associated with more frequent episodes of acute rejection and progression to chronic allograft nephropathy. Alloantigen-independent inflammation is an important process, participati...
متن کاملImmune modulation of acute kidney injury.
A cute kidney injury (AKI), inclusive of clinical terms such as acute renal failure, acute tubular necrosis, and delayed graft function, is being defined as functional or structural abnormalities or markers of kidney damage, including abnormalities in blood, urine, or tissue tests or imaging studies present for 3 months (Acute Kidney Injury Network group proposed consensus definition; personal ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Immunology
سال: 2009
ISSN: 1521-6616
DOI: 10.1016/j.clim.2008.08.016